Academic email chain discussing gene subfunctionalization among researchers

From: Robert Trivers _ a | Sent: 4/14/2018 5:06:12 PM To: Alan Rogers |i « Jeffrey Epstein [jeevacation@gmail.com] cc: Gordon Getty i Oliver Goodenough | | Tim Kane EE, Rob Hanson i: Paul Zak |); Bobby McCormick | ey Anderson EE); Clive Crook | iE, ); (Viatt Ridley Ee |; Gerry Ohrstrom iS ; Lee Silver (iy Monika Gruter Cheney (iE : Dane Stangler RR on Bailey (TE ; Aona Oreber ES: Anula Jayasuriya |; Paul Romer (Ds; Vike Cagney |i: Evan Sith Roger Edelen [ES]; Bill Prezant i) John Mallen (x ; Jim Halligan i \Varcuerite Atkins (iE); Alex.Family Pines (PS |; Ditsa Pines | avid Car st |e |; president@usfca.edu; Clair Brown |i ; (Vis. Yvette Robbins Richerson, Peter) Subject: Re: Free Growth (09-29-17) part 2.pdf Importance: — High yes Alan i think you are you are referring to duplication of a gene—there are many such genes including those produced by retrotransposons (as evidenced by lack of introns)—where a gene has two separate effects and there is an advantage to having a gene with each effect you will often prefer two genes to one, because of less interference in fitness effects Peter was talking about a gene with a single effect—sickling—and the other allele is the normal one—the heterozygote destroys malaria within red blood cells at trivial cost and there is no cost at all if malaria is not present—by contrast homozygous sickle individuals suffer lifetime effects Peter was trying to conjure up a heterozygote that propagated asexually but this requires a chiasma between neighbouring genes, a very rare event and hence it usually leads rapidly to mutational decay of one of the two copies, i.e. so-called pseudogenes, of which there are many in our genome in haste On Thu, Apr 12, 2018 at 11:02 PM, Alan Rogers > wrote: haven't read whatever Pete wrote, but if I understand Bob correctly, Pete must be talking about subfunctionalization: https://en.wikipedia.org/wiki/Subfunctionalization so, it's not a radical suggestion. It's thought to be the process that gave rise to all multi-gene families. Michael Lynch discusses it in his book, The Origin of Genome Architecture. Am I missing something? Alan On Thu, Apr 12, 2018 at 3:03 PM, Robert Trivers (> wrote: HOUSE_OVERSIGHT_025589