From: J <jeevacation@grnail.com>

From: J <jeevacation@grnail.com> To: Bryan Bishop Subject: Re: Chinese edited embryos are mosaic... Date: Mon, 26 Nov 2018 17:09:39 +0000 great On Mon, Nov 26, 2018 at 11:58 AM Bryan Bishop < > wrote: I am sure you have seen the news. Short version of the core technical problem, there's high mosaicism because of their technique, meaning only a low percentage of cells in the body have any of the modifications. https://www.technologyreview.corn/s/612458/exclusive-chinese-scientists-are-creating-crispr-babies/ https://www.bloomberg.corn/news/articles/2018-11-26/urgent-ap-exclusive-first-gene-edited-babies-claimed- in-china https://www.technologyreview.com/s/612465/crispr-inventor-feng-zhang-calls-for-moratorium-on-baby- making/ My team has been working on a new technique which does not involve stem cells in the testis, instead it's an embryo editing technique more similar to cloning which does not require an injection to the biodad. The idea hit us like a bolt of lightning so we're moving along in that direction. Meanwhile our overseas lab has reported some mouse testis transfection results. They are observing maybe 5% transfection efficiency, which might be enough, further testing is ongoing. But ultimately this method is inferior to our new embryo modification technique. Talk soon. - Bryan please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to jeevacation@gmail.com, and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved EFTA01015485